Athearn SD40-2's are designed work on tight turns. They were introduced in 1984 and the tolerances are pretty loose so they should make it without too much difficulty. Newer 6 axle locos are built to tighter tolerances and are much less likely to be able to make an 18" curve.
Most should work on 22", but if you're buying a state-of-the-art high-end loco it's never a bad idea to ask for folks experience with a specific loco. The good news is that there's alot of Athearn Blue-Box stock out there in good shape.
That said, it sounds like you like the look of a Big Safety cab modern loco. I don't know about the SD70 (Athern's version is "Genesis" series), but maybe Blue Box C44-9W and AC4400CW might work on 18" curves. Definitely don't buy one on my suggestion, though perhaps someone else can give you better advice.
One other thing to consider is that perhaps you can re-gauge the center axle on each truck to have a bit more play.
Lastly, there are some 4-Axle Safety Cab locos that have much of the modern "look". GP60M perhaps? There are a number of makers. Walthers had an 8-40BW until recently and Atlas makes it too. I'd still advise asking for personal experience, but if you're buying a new-production locomotive, I think sticking to a 4 axle is best. Lastly, a shorter 4 axle loco will look much better around small curves than a longer 6 axle.