Mine is frameless, using L girders and cross members (which I call stringers). The legs are 1x4s, with countersunk screws and wood glue making a half-square. VERY stable legs. Same for the L gjrders. Crossmembers are screwed only so they can be moved if needed.
As you’re building yours framed, what will be on top? Plywood screwed to the frame? If so, glue would probably not be needed unless it’s luan or extremely thin. If extruded foam only, then I would use glue & screws functioning as clamps… which is what they are truth be told.
Pocket holes are really only for furniture where the hardware needs to be hidden from all viewing angles like cabinetry, drawers, dining tables etc. But whatever entertains you works I guess,